Abstract:
PURPOSE:
To evaluate the efficacy of time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT) in differentiating between optic nerve head drusen (ONHD) and optic disc oedema (ODE).
METHODS:
We studied 66 patients with ONHD, 31 patients with ODE, and 70 controls using TD-OCT and SD-OCT. We analysed two aspects of the tomographic findings: (i) quantitative, through measurement of the retinal nerve fibre layer (RNFL) and papillary elevation; and (ii) qualitative, through assessment of the hyporeflective space, morphology of the internal contour, focal papillary mass and RNFL increases in seven contiguous clock hours. We evaluated the sensitivity, specificity, intra-class correlation coefficient (ICC), and inter-observer agreement (κ).
RESULTS:
The quantitative analysis of the RNFL revealed an average thickness of the RNFL <124μm with TD-OCT (sensitivity=91%; specificity=94%) and <116μm with SD-OCT (sensitivity=91%; specificity=97%). The thickness of the nasal quadrant was <108μm with TD-OCT (sensitivity=89%; specificity=87%) and with SD-OCT was <92μm (sensitivity=88%; specificity=94%), however without significant differences between the nasal, ...