Mostrar el registro sencillo del ítem
dc.contributor.author | Sala Vila, Aleix | |
dc.contributor.author | Fernández Jiménez, Rodrigo | |
dc.contributor.author | Pizarro, Gonzalo | |
dc.contributor.author | Calvo, Carlos | |
dc.contributor.author | García Ruiz, José María | |
dc.contributor.author | Fernández Friera, Leticia | |
dc.contributor.author | Rodríguez, Maite D. | |
dc.contributor.author | Escalera, Noemí | |
dc.contributor.author | Palazuelos, Jorge | |
dc.contributor.author | Macías, Ángel | |
dc.contributor.author | Pérez Asenjo, Braulio | |
dc.contributor.author | Fernández Ortíz, Antonio | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Fuster, Valentín | |
dc.contributor.author | Ibáñez Cabeza, Borja | |
dc.date.accessioned | 2018-04-04T11:38:27Z | |
dc.date.available | 2018-04-04T11:38:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Sala-Vila, A., Fernández-Jiménez, R., Pizarro, G., Calvo, C., García-Ruiz, J. M., Fernández-Friera, L., ... & Pérez-Asenjo, B. (2017). Nutritional preconditioning by marine omega-3 fatty acids in patients with ST-segment elevation myocardial infarction: A METOCARD-CNIC trial substudy. International Journal of Cardiology, 228, 828-833. DOI:10.1016/j.ijcard.2016.11.214 | spa |
dc.identifier.issn | 0167-5273 | |
dc.identifier.issn | 1874-1754 | |
dc.identifier.uri | http://hdl.handle.net/11268/7177 | |
dc.description.abstract | Background: Marine omega-3 eicosapentaenoic acid (EPA) is readily incorporated into cardiomyocyte membranes, partially displacing the omega-6 arachidonic acid (AA). Whereas AA is a substrate for pro-inflammatory eicosanoids, the release of EPA from cell membranes generates anti-inflammatory lipid mediators, contributing to the infarct-limiting effect observed experimental models. Clinical data are lacking. Methods: In this observational study conducted in 100 patients with a reperfused anterior ST-elevation myocardial infarction (STEMI), at hospital admission we quantified by gas-chromatography the red blood cell proportions of AA, EPA, and the AA:EPA ratio, a valid surrogate for cardiomyocyte membrane content. Patients underwent cardiac magnetic resonance imaging in the acute phase (one week post-STEMI), and at long-term (6 months) follow-up. Infarct size (delayed gadolinium enhancement) and cardiac function (left ventricular ejection fraction [LVEF]) were correlated with exposures of interest by multivariate regression analysis. Results: AA:EPA ratio directly related to acute infarct size (coefficient [95% CI]: 6.19 [1.68 to 10.69], P = 0.008) and inversely to long-term LVEF (coefficient [95% CI]: − 4.02 [− 7.15 to − 0.89], P = 0.012). EPA inversely related to acute infarct size (coefficient [95% CI]: − 6.58; [− 11.46 to − 1.70]; P = 0.009), while a direct association with LVEF at follow-up (coefficient [95% CI]: 3.67 [0.25 to 7.08]; P = 0.036) was observed. Conclusions: A low AA:EPA ratio in red blood cells at the time of STEMI is associated with smaller acute infarct size and preserved long-term ventricular function. Our results are consistent with prior work in experimental models and add to the notion of omega-3 fatty acids as a healthy fat. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Nutritional preconditioning by marine omega-3 fatty acids in patients with ST-segment elevation myocardial infarction: A METOCARD-CNIC trial substudy | spa |
dc.type | article | spa |
dc.description.impact | 4.034 JCR (2017) Q2, 41/128 Cardiac and Cardiovascular Systems | spa |
dc.identifier.doi | 10.1016/j.ijcard.2016.11.214 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Infarto de miocardio | spa |
dc.subject.uem | Ácidos grasos | spa |
dc.subject.unesco | Enfermedad cardiovascular | spa |
dc.subject.unesco | Nutrición | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |