Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): A retrospective case series
Scheltema, Nienke M.; Gentile, Angela; Lución, Florencia; Nokes, D. James; Munywoki, Patrick K.; Madhi, Shabir A.; Groome, Michelle J.; Cohen, Cheryl; Moyes, Jocelyn; Thorburn, Kentigern; Thamthitiwat, Somsak; Oshitani, Hitoshi; Lupisán, Socorro P.; Gordon, Aubree; Sánchez, José F.; O'Brien, Katherine L.; Gessner, Bradford D.; Sutanto, Agustinus; Mejías, Asunción; Ramilo, Octavio; Khuri-Bulos, Najwa; Halasa, Natasha; París, Fernanda de; Pirès, Márcia Rosane; Spaeder, Michael C.; Paes, Bosco A.; Simões, Eric A. F.; Leung, Ting F.; Da Costa Oliveira, Maria Tereza; Freitas Lázaro Emediato, Carla Cecilia de; Bassat, Quique; Butt, Warwick; Aamir, Uzma Bashir; Ali, Asad; Lucero, Marilla G.; Fasce, Rodrigo A.; López, Olga; Rath, Bárbara A.; Polack, Fernando P.; Papenburg, Jesse; Roglić, Srđan; Ito, Hisato; Goka, Edward A.; Grobbee, Diederick E.; Nair, Harish; Bont, Louis J.
Fecha:
2017
Materia UNESCO:
Aparato respiratorio
Materia UNESCO:
Niño
Materia UNESCO:
Tratamiento médico
Tipo:
article
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Resumen:
Background:
Respiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data.
Methods:
In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. For the literature search, we searched PubMed for articles published up to Feb 3, 2015, using the key terms “RSV”, “respiratory syncytial virus”, or “respiratory syncytial viral” combined with “mortality”, “fatality”, “death”, “died”, “deaths”, or “CFR” for articles published in English. We invited researchers and clinicians identified to participate between Nov 1, 2014, and Oct 31, 2015. We calculated descriptive statistics for all variables.
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