Resumen:
We assessed liver stiffness measurement (LSM) for the prediction of mortality and decompensation in HIVinfected
patients with compensated liver cirrhosis. A prospective cohort study of HIV-infected patients with confirmed liver cirrhosis from 9 hospitals in Spain.
LSM was undertaken for each patient; clinical events were collected prospectively after the baseline visit, and patients
were followed until death or the censoring date. We used univariate/multivariate Cox proportional hazard models to
evaluate the utility of LSM for predicting the first hepatic decompensation or overall mortality. The sensitivity (SEN),
specificity (SPE), positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+) and
negative likelihood ratio (LR-) were calculated. The LSM cutoff was selected using ROC curves. We included 102 patients with compensated liver cirrhosis; median [interquartile, (IQR)] follow-up was
36 (21-46) months, median (IQR) CD4+ cell count was 415 cells/μL (307-624) and 94% were receiving antiretroviral
therapy. The median (IQR) LSM was 17 kPa (11.7-26). Nineteen events were recorded during follow-up. Multivariate
analysis showed that time to hepatic ...