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dc.contributor.author | Sánchez-Quintana, Damián | |
dc.contributor.author | López Mínguez, José Ramón | |
dc.contributor.author | Pizarro, Gonzalo | |
dc.contributor.author | Murillo Haba, Margarita | |
dc.contributor.author | Cabrera Rodríguez, José Ángel | |
dc.date.accessioned | 2017-02-22T19:13:41Z | |
dc.date.available | 2017-02-22T19:13:41Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Sánchez-Quintana, D., Ramon Lopez-Minguez, J., Pizarro, G., Murillo, M., y Angel Cabrera, J. (2012). Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation. Current cardiology reviews, 8(4), 310-326. | spa |
dc.identifier.issn | 1573403X | |
dc.identifier.uri | http://hdl.handle.net/11268/6214 | |
dc.description.abstract | The definition of atrial fibrillation (AF) as a functional electrical disorder does not reflect the significant underlying structural abnormalities. Atrial and Pulmonary Vein (PV) muscle sleeve microstructural remodeling is present, and establishes a vulnerable substrate for AF maintenance. In spite of an incomplete understanding of the anatomo-functional basis for AF, current evidence demonstrates that this arrhythmia usually requires a trigger for initiation and a vulnerable electrophysiological and/or anatomical substrate for maintenance. It is still unclear whether the trigger mechanisms include focal enhanced automaticity, triggered activity and/or micro re-entry from myocardial tissue. Initiation of AF can be favored by both parasympathetic and sympathetic stimulation, which also seem to play a role in maintaining AF. Finally, evolving clinical evidence demonstrates that inflammation is associated with new-onset and recurrent AF through a mechanism that possibly involves cellular degeneration, apoptosis, and subsequent atrial fibrosis. © 2012 Bentham Science Publishers. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation | spa |
dc.type | article | spa |
dc.description.impact | 0.546 SJR (2012) Q2, 2321/6630 Medicine, 139/332 Cardiology and cardiovascular medicine | spa |
dc.identifier.doi | 10.2174/157340312803760721 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Cardiología | spa |
dc.subject.uem | Vasos sanguíneos | spa |
dc.subject.uem | Aparato respiratorio | spa |
dc.subject.unesco | Sistema cardiovascular | spa |
dc.subject.unesco | Aparato respiratorio | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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