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dc.contributor.author | Lucía Mulas, Alejandro | |
dc.contributor.author | Gómez Gallego, Félix | |
dc.contributor.author | Chicharro, José L. | |
dc.contributor.author | Hoyos, J. | |
dc.contributor.author | Celaya, K. | |
dc.contributor.author | Córdova, Alfredo | |
dc.contributor.author | Earnest, C. P. | |
dc.date.accessioned | 2016-08-01T08:39:09Z | |
dc.date.available | 2016-08-01T08:39:09Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Lucía, A., Gómez-Gallego, F., Chicharro, J. L., Hoyos, J., Celaya, K., Córdova, A.,… & Earnest, C. P. (2005). Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races?. International Journal of Sports Medicine, 26(6), 442-447. | spa |
dc.identifier.issn | 01724622 | |
dc.identifier.issn | 14393964 | |
dc.identifier.uri | http://hdl.handle.net/11268/5526 | |
dc.description.abstract | In this paper, we examine the association between polymorphisms of the angiotensin-converting enzyme (ACE) and muscle-specific creatine kinase (CKMM) genes, and the actual performance status observed in professional cyclists capable of completing a classic tour stage race such as the Giro d'Italia, Tour de France, or Vuelta a España. To accomplish this, we compared the frequencies of the ACE and CKMM genotypes/alleles in 50 top-level Spanish professional cyclists that have completed at least one of these events to 119 sedentary controls, and 27 elite (Olympic-class) Spanish runners. The genetic polymorphism at the CK-MM locus was detected with the NcoI restriction endonuclease. The results of our study showed that the proportion of the DD genotype was higher in cyclists (50.0 %) than in the other two groups (p < 0.05), the proportion of the ID genotype was higher in controls (46.2 %) than in the other two groups (p < 0.05), and the proportion of the II genotype was higher in runners (40.7 %) than in the other two groups (p < 0.05). The proportion of the D allele was higher in both cyclists (65.0 %) and controls (57.6 %) than in runners (46.3 %) (p < 0.001), whereas the proportion of the I allele was higher in runners than in the other two groups (p < 0.001). No statistical differences were found for CKK-MM-NcoI. We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour race, the frequency distribution of the D allele and the DD genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent). | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-week races? | spa |
dc.type | article | spa |
dc.description.impact | 1.433 JCR (2005) Q2, 21/70 Sport sciences | spa |
dc.identifier.doi | 10.1055/s-2004-821108 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Ciclismo - Aspectos fisiológicos | spa |
dc.subject.uem | Medicina deportiva - Ciclismo | spa |
dc.subject.unesco | Medicina deportiva | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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