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dc.contributor.author | Eynon, Nir | spa |
dc.contributor.author | Ruiz, Jonatan R. | spa |
dc.contributor.author | Meckel, Yoav | spa |
dc.contributor.author | Morán, María | spa |
dc.contributor.author | Lucía Mulas, Alejandro | spa |
dc.date.accessioned | 2013-11-27T17:26:13Z | |
dc.date.available | 2013-11-27T17:26:13Z | |
dc.date.issued | 2011 | spa |
dc.identifier.citation | Eynon, N., Ruiz, J. R., Meckel, Y., Morán, M., & Lucía-Mulas, A. (2011). Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion, 11(1), 64-69. | spa |
dc.identifier.issn | 18728278 | spa |
dc.identifier.uri | http://hdl.handle.net/11268/549 | |
dc.description.abstract | We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis. | spa |
dc.language.iso | eng | spa |
dc.subject.other | Polymorphism, Genetic* | spa |
dc.subject.other | Athletic Performance/*Physiology | spa |
dc.subject.other | European Continental Ancestry Group/*Genetics | spa |
dc.subject.other | Mitochondria/*Genetics | spa |
dc.subject.other | Physical Endurance/*Genetics | spa |
dc.subject.other | Transcription Factors/*Genetics | spa |
dc.subject.other | Athletes | spa |
dc.subject.other | Female | spa |
dc.subject.other | Gene Frequency | spa |
dc.subject.other | Genotype | spa |
dc.subject.other | Heat-Shock Proteins/Genetics | spa |
dc.subject.other | Humans | spa |
dc.subject.other | Israel | spa |
dc.subject.other | Male | spa |
dc.subject.other | Middle Aged | spa |
dc.subject.other | Mitochondria/Metabolism | spa |
dc.subject.other | Ppar Delta/Genetics | spa |
dc.subject.other | Physical Endurance/Physiology | spa |
dc.subject.other | Sports | spa |
dc.subject.other | Transcription Factors/Metabolism | spa |
dc.title | Mitochondrial biogenesis related endurance genotype score and sports performance in athletes | spa |
dc.type | article | spa |
dc.description.impact | 3.615 JCR (2011) Q2, 78/181 Cell biology, 45/158 Genetics & heredity | spa |
dc.identifier.doi | 10.1016/j.mito.2010.07.004 | spa |
dc.rights.accessRights | closedAccess | en |
dc.subject.unesco | Genética humana | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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