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dc.contributor.author | Palao Suay, Raquel | |
dc.contributor.author | Aguilar de Armas, María Rosa | |
dc.contributor.author | Parra Ruiz, F. J. | |
dc.contributor.author | Fernández Gutiérrez, M. | |
dc.contributor.author | Parra, J. | |
dc.contributor.author | Sánchez Rodríguez, Carolina | |
dc.contributor.author | Sanz Fernández, Ricardo | |
dc.contributor.author | Rodrigáñez Riesco, Laura | |
dc.contributor.author | Román, J. S. | |
dc.date.accessioned | 2015-06-19T07:12:43Z | |
dc.date.available | 2015-06-19T07:12:43Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Palao-Suay, R., Aguilar, M. R., Parra-Ruiz, F. J., Fernández-Gutiérrez, M., Parra, J., Sánchez-Rodríguez, C., ... & Román, J. S. (2015). Anticancer and Antiangiogenic Activity of Surfactant-Free Nanoparticles Based on Self-Assembled Polymeric Derivatives of Vitamin E: Structure–Activity Relationship. Biomacromolecules, 16(5), 1566-1581. | spa |
dc.identifier.issn | 15257797 | |
dc.identifier.issn | 15264602 | |
dc.identifier.uri | http://hdl.handle.net/11268/4020 | |
dc.description.abstract | α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring. | spa |
dc.language.iso | eng | spa |
dc.title | Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship | spa |
dc.type | article | spa |
dc.description.impact | 5.583 JCR (2015) Q1, 41/289 Biochemistry & molecular biology, 6/59 Chemistry, organic, 5/82 Polymer science | spa |
dc.identifier.doi | 10.1021/acs.biomac.5b00130 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Vitaminas | spa |
dc.subject.uem | Cáncer | spa |
dc.subject.unesco | Salud | spa |
dc.subject.unesco | Ciencias médicas | spa |
dc.subject.unesco | Cáncer | spa |
dc.subject.unesco | Vitamina | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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