Resumen:
Ethnopharmacological relevance: A common plant used to treat several gastric disorders is Buddleja scordioides Kunth,commonly known as salvilla.
Aim of thes tudy: To detect inflammatory markers,in order to evaluate the gastroprotective potential of
salvilla infusions,as this could have beneficial impact on the population exposed to gastric ulcers and
colitis.
Materials and methods: The present work attempted infusions were prepared with B. scordioides (1% w/w) lyophilized and stored.Total phenolic content and GC–MS analysis were performed. Wistar rats were
divided into five groups a negative vehicle control,an indomethacin group,and three
experimental groups,named preventive,curative,and suppressive. All rats were sacrificed under deep
ether anesthesia(6h)after the last oral administration of indomethacin/infusion.The rat stomachs were
promptly excised,weighed,and chilled in ice-cold and 0.9%NaCl.Histological analysis,nitrites
quantification and immunodetection assays were done.
Results: B.scordioides infusions markedly reduced the visible hemorrhagic lesions induced byindomethacin in rat stomachs,also showed down-regulation of COX2, IL-8 and TNFα and up-regulation of
COX-1with a moder...