Abstract:
Hyperuricemia has been related with the development of arterial hypertension Cystatin C, a marker of renal function has been proposed recently as a marker of cardiovascular risk, independently of renal function. We investigate if serum uric acid is related with serum cystatin C in patients with essential hypertension. We included 885 patients (50.7% males), aged 57,8 +/- 14,9 y., diagnosed of essential hypertension and attended in our Hypertension Unit during a 12 month. We performed in all of them a clinical history, a physical examination and routine analysis, including cystatin C (Nephelometry, Behring). Hyperuricemia was defined as serum uric acid > 7 mg/dl (males) or >6 mg/dl (females) or being on treatment with allopurinol. The result was that 272 patients had hyperuricemia (30,7%) with male predominance (36.1%) vs. females (25.5%), [p < 0.0001]. Serum cystatin C did not shown gender differences (males 0.87 +/- 0.269 mg/L and females (0.90 +/- 0.47 mg/L), [p: 0.061]. After adjusting for age, gender, estimated glomerular filtration rate (e-GFR) and diuretic (38.2%) and allopurinol treatment (8.1%), serum uric acid showed a positive correlation with abdominal circumference(r:0.277, p< 0,0001)...