Mostrar el registro sencillo del ítem
dc.contributor.author | Pinós, Tomás | spa |
dc.contributor.author | Fuku, Noriyuki | spa |
dc.contributor.author | Cámara, Yolanda | spa |
dc.contributor.author | Arai, Yasumichi | spa |
dc.contributor.author | Abe, Yukiko | spa |
dc.contributor.author | Rodríguez Romo, Gabriel | spa |
dc.contributor.author | Garatachea, Nuria | spa |
dc.contributor.author | Santos-Lozano, Alejandro | spa |
dc.contributor.author | Miro-Casas, Elisabet | spa |
dc.contributor.author | Ruiz-Meana, Marisol | spa |
dc.contributor.author | Otaegui, Imanol | spa |
dc.contributor.author | Murakami, Haruka | spa |
dc.contributor.author | Miyachi, Motohiko | spa |
dc.contributor.author | García-Dorado, David | spa |
dc.contributor.author | Hinohara, Kunihiko | spa |
dc.contributor.author | Andreu, Antoni L. | spa |
dc.contributor.author | Kimura, Akinori | spa |
dc.contributor.author | Hirose, Nobuyoshi | spa |
dc.contributor.author | Lucía Mulas, Alejandro | spa |
dc.date.accessioned | 2014-03-18T10:07:04Z | |
dc.date.available | 2014-03-18T10:07:04Z | |
dc.date.issued | 2014 | spa |
dc.identifier.citation | Pinós, T., Fuku, N., Cámara, Y., Arai, Y., Abe, Y., Rodríguez-Romo, G., …, & Lucía-Mulas, A. (2014). The rs1333049 polymorphism on locus 9p21. 3 and extreme longevity in Spanish and Japanese cohorts. Age, 36(2), 933-943. | spa |
dc.identifier.uri | http://hdl.handle.net/11268/1947 | |
dc.description.abstract | The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n = 152, 128 women, 100–111 years; healthy controls: n = 343, 212 women, age <50 years; CAD controls: n = 98, 32 women, age ≤65 years) and Japanese (centenarians: n = 742, 623 women, 100–115 years; healthy controls: n = 920, 511 women, < 60 years; CAD controls: n = 395, 45 women, age ≤65 years). The frequency of the “risk” C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P = 0.088) or CAD controls (55.1 %, P = 0.078), and significant differences were found in genotype distributions (P = 0.034 and P = 0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P = 0.602), but it was significantly lower in the former than in CAD controls (57.2 %, P < 0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23–26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population. | spa |
dc.language.iso | eng | spa |
dc.title | The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts | spa |
dc.type | article | spa |
dc.description.impact | 3.390 JCR (2014) Q2, 14/50 Geriatrics and gerontology | spa |
dc.identifier.doi | 10.1007/s11357-013-9593-0 | spa |
dc.rights.accessRights | closedAccess | en |
dc.subject.unesco | Genética humana | spa |
dc.subject.unesco | Vejez | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |