Abstract:
Objective: to evaluate the efficacy of dietary supplementation with a combination of antioxidants (lipoic acid, N-acetylcysteine, vitamin B6, and S-adenosyl-l-methionine) for the modulation of metabolic, endocrine, and clinical parameters in comparison with oral contraception in non-diabetic women newly diagnosed with polycystic ovary syndrome (PcOs).
Methods: this was a prospective, partially randomized, multicenter study in which non-diabetic women with PcOs were recruited under routine clinical practice conditions and distributed in three groups to receive the following regimen for 6months: 1) antioxidant combination (MN group); 2) oral contraception (Oc group); or 3) oral contraception and the antioxidant combination (MN + Oc group). General recommendation of healthy diet and regular exercise was given to all patients. Metabolic, endocrine, clinical, and quality of life parameters were recorded at baseline and after 6months of therapy.
Results: a total of 96 women with PcOs were included in the study. after 6months of treatment, the homeostasis model assessment-estimated insulin resistance (hOMa-iR) level was reduced only in the MN group, with a significant mean reduction of −0.92 points. a...