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dc.contributor.author | García Merino, José Ángel | |
dc.contributor.author | Lucas Moreno, Beatriz de | |
dc.contributor.author | Herrera Rocha, Karen | |
dc.contributor.author | Moreno Pérez, Diego | |
dc.contributor.author | Montalvo Lominchar, María Gregoria | |
dc.contributor.author | Fernández Romero, Arantxa | |
dc.contributor.author | Santiago Dorrego, Catalina | |
dc.contributor.author | Pérez Ruiz, Margarita | |
dc.contributor.author | Larrosa Pérez, Mar | |
dc.date.accessioned | 2022-09-12T10:43:20Z | |
dc.date.available | 2022-09-12T10:43:20Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | García-Merino, J. A., de Lucas, B., Herrera-Rocha, K., Moreno-Pérez, D., Montalvo-Lominchar, M. G., Fernández-Romero, A., Santiago, C., Pérez-Ruiz, M., & Larrosa, M. (2022). Flavanol-Rich Cocoa Supplementation Inhibits Mitochondrial Biogenesis Triggered by Exercise. Antioxidants, 11(8), 1522. https://doi.org/10.3390/antiox11081522 | spa |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://hdl.handle.net/11268/11586 | |
dc.description.abstract | The potential role of cocoa supplementation in an exercise context remains unclear. We describe the effects of flavanol-rich cocoa supplementation during training on exercise performance and mitochondrial biogenesis. Forty-two male endurance athletes at the beginning of the training season received either 5 g of cocoa (425 mg of flavanols) or maltodextrin (control) daily for 10 weeks. Two different doses of cocoa (equivalent to 5 g and 15 g per day of cocoa for a 70 kg person) were tested in a mouse exercise training study. In the athletes, while both groups had improved exercise performance, the maximal aerobic speed increased only in the control group. A mitochondrial DNA analysis revealed that the control group responded to training by increasing the mitochondrial load whereas the cocoa group showed no increase. Oxidative stress was lower in the cocoa group than in the control group, together with lower interleukin-6 levels. In the muscle of mice receiving cocoa, we corroborated an inhibition of mitochondrial biogenesis, which might be mediated by the decrease in the expression of nuclear factor erythroid-2-related factor 2. Our study shows that supplementation with flavanol-rich cocoa during the training period inhibits mitochondrial biogenesis adaptation through the inhibition of reactive oxygen species generation without impacting exercise performance. | spa |
dc.description.sponsorship | Ministry of Economy and Competitiveness, Spain (project AGL2016-77288-R) | spa |
dc.description.sponsorship | Ministry of Education, Culture and Sports, Spain (FPU grant 2016/01110) | spa |
dc.description.sponsorship | European Social Fund through the Operational Program for Youth Employment and the Youth Employment Initiative of the Community of Madrid (PEJD-2018-POST/SAL-8404 and PEJ-2017-TL/SAL-6114) | spa |
dc.language.iso | eng | spa |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.other | Antioxidantes | spa |
dc.subject.other | Cacao | spa |
dc.title | Flavanol-Rich Cocoa Supplementation Inhibits Mitochondrial Biogenesis Triggered by Exercise | spa |
dc.type | article | spa |
dc.description.impact | 7.675 JCR (2021) Q1, 50/297 Biochemistry & Molecular Biology | spa |
dc.description.impact | 1.008 SJR (2021) Q1, 29/119 Clinical Biochemistry | spa |
dc.description.impact | No data IDR 2021 | spa |
dc.identifier.doi | 10.3390/antiox11081522 | |
dc.rights.accessRights | openAccess | spa |
dc.subject.unesco | Deporte | spa |
dc.subject.unesco | Bioquímica | spa |
dc.subject.unesco | Biología molecular | spa |
dc.description.filiation | UEM | spa |
dc.relation.publisherversion | https://doi.org/10.3390/antiox11081522 | spa |
dc.peerreviewed | Si | spa |