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dc.contributor.author | Poddubnyy, Denis | |
dc.contributor.author | Sieper, Joachim | |
dc.contributor.author | Akar, Servet | |
dc.contributor.author | Muñoz Fernández, Santiago | |
dc.contributor.author | Haibel, Hildrun | |
dc.contributor.author | Hojnik, Maja | |
dc.contributor.author | Ganz, Fabiana | |
dc.contributor.author | Inman, Robert D. | |
dc.date.accessioned | 2022-08-04T11:32:34Z | |
dc.date.available | 2022-08-04T11:32:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Poddubnyy, D., Sieper, J., Akar, S., Muñoz-Fernández, S., Haibel, H., Hojnik, M., Ganz, F., & Inman, R. D. (2021). Characteristics of Patients With Axial Spondyloarthritis by Geographic Regions: PROOF Multicountry Observational Study Baseline Results. Rheumatology (Oxford, England), 61(8), 3299–3308. https://doi.org/10.1093/rheumatology/keab901 | spa |
dc.identifier.issn | 1462-0324 | |
dc.identifier.issn | 1462-0332 | |
dc.identifier.uri | http://hdl.handle.net/11268/11561 | |
dc.description.abstract | To compare demographic and clinical characteristics of patients with axial spondyloarthritis (axSpA) across geographic regions. Methods: PROOF is an observational study that enrolled recently diagnosed (≤1 year) axSpA patients fulfilling the Assessment of SpondyloArthritis international Society classification criteria from rheumatology clinical practices in 29 countries across 6 geographic regions. Demographics and disease-related parameters were collected. Here we present baseline data for patients who had classification as radiographic (r-)axSpA or non-radiographic (nr-axSpA) confirmed by central reading. Results: Of the 2170 patients enrolled, 1553 were classified based on central evaluation of sacroiliac radiographs (r-axSpA: 1023 [66%]; nr-axSpA: 530 [34%]). Patients with nr-axSpA had significantly higher occurrence of enthesitis (40% vs 33%), psoriasis (10% vs 5%), and inflammatory bowel disease (IBD, 4% vs 2%) vs r-axSpA patients. Significant differences in axSpA characteristics were observed between geographic regions. The highest occurrence of peripheral arthritis (60%), enthesitis (52%), and dactylitis (12%) was in Latin America and the lowest in Canada (9%, 9%, and 2% respectively). Occurrence of uveitis (18%) and psoriasis (14%) was highest in Canada and lowest in China (6% and <1%). IBD was highest in Arabia (21%); no cases were observed in China. In multivariable analysis adjusted for factors potentially affecting peripheral and extra-musculoskeletal manifestations, geographic regions still exhibited significant differences in frequencies of uveitis (p<0.01), psoriasis (p<0.0001) and peripheral arthritis (p<0.0001). Conclusions: The multinational PROOF study of axSpA patients showed significant regional differences in peripheral and extra-musculoskeletal manifestations of SpA, which could be considered in management guidelines and clinical trials. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.rights | Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
dc.subject.other | Espondiloartritis | spa |
dc.subject.other | Reumatología | spa |
dc.subject.other | Signos y síntomas | spa |
dc.title | Characteristics of Patients With Axial Spondyloarthritis by Geographic Regions: PROOF Multicountry Observational Study Baseline Results | spa |
dc.type | article | spa |
dc.description.impact | 7.046 JCR (2021) Q1, 6/34 Rheumatology | spa |
dc.description.impact | 1.563 SJR (2021) Q1, 15/265 Pharmacology (medical) | spa |
dc.description.impact | No data IDR 2021 | spa |
dc.identifier.doi | 10.1093/rheumatology/keab901 | |
dc.rights.accessRights | openAccess | spa |
dc.subject.unesco | Enfermedad | spa |
dc.subject.unesco | Demografía | spa |
dc.subject.unesco | Estudio de caso | spa |
dc.description.filiation | UEM | spa |
dc.relation.publisherversion | https://doi.org/10.1093/rheumatology/keab901 | spa |
dc.peerreviewed | Si | spa |