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dc.contributor.author | González Guerra, Andrés | |
dc.contributor.author | Roche Molina, Marta | |
dc.contributor.author | García Quintáns, Nieves | |
dc.contributor.author | Sánchez Ramos, Cristina | |
dc.contributor.author | Martín Pérez, Daniel | |
dc.contributor.author | Lytvyn, Mariya | |
dc.contributor.author | Nicolás Hernández, Javier de | |
dc.contributor.author | Rivera Torres, José | |
dc.contributor.author | Arroyo, Diego F. | |
dc.contributor.author | Sanz Rosa, David | |
dc.contributor.author | Bernal, Juan Antonio | |
dc.date.accessioned | 2022-01-14T15:53:39Z | |
dc.date.available | 2022-01-14T15:53:39Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | González-Guerra, A., Roche-Molina, M., García-Quintáns, N., Sánchez-Ramos, C., Martín-Pérez, D., Lytvyn, M., Nicolás-Hernández, J., Rivera-Torres, J., Arroyo, D. F., Sanz-Rosa, D., & Bernal, J. A. (2021). Sustained Elevated Blood Pressure Accelerates Atherosclerosis Development in a Preclinical Model of Disease. International Journal of Molecular Sciences, 22(16), 8448. https://doi.org/10.3390/IJMS22168448 | spa |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/11268/10563 | |
dc.description.abstract | The continuous relationship between blood pressure (BP) and cardiovascular events makes the distinction between elevated BP and hypertension based on arbitrary cut-off values for BP. Even mild BP elevations manifesting as high-normal BP have been associated with cardiovascular risk. We hypothesize that persistent elevated BP increases atherosclerotic plaque development. To evaluate this causal link, we developed a new mouse model of elevated BP based on adeno-associated virus (AAV) gene transfer. We constructed AAV vectors to support transfer of the hRenin and hAngiotensinogen genes. A single injection of AAV-Ren/Ang (1011 total viral particles) induced sustained systolic BP increase (130 ± 20 mmHg, vs. 110 ± 15 mmHg in controls; p = 0.05). In ApoE−/− mice, AAV-induced mild BP elevation caused larger atherosclerotic lesions evaluated by histology (10-fold increase vs. normotensive controls). In this preclinical model, atheroma plaques development was attenuated by BP control with a calcium channel blocker, indicating that a small increase in BP within a physiological range has a substantial impact on plaque development in a preclinical model of atherosclerosis. These data support that non-optimal BP represents a risk for atherosclerosis development. Earlier intervention in elevated BP may prevent or delay morbidity and mortality associated with atherosclerosis. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.other | Aterosclerosis | spa |
dc.subject.other | Parvoviridae | spa |
dc.subject.other | Prehipertensión | spa |
dc.title | Sustained Elevated Blood Pressure Accelerates Atherosclerosis Development in a Preclinical Model of Disease | spa |
dc.type | article | spa |
dc.description.impact | 6.208 JCR (2021) Q1, 69/297 Biochemistry & Molecular Biology | spa |
dc.description.impact | 1.176 SJR (2021) Q1, 128/729 Computer Science Applications | spa |
dc.description.impact | No data IDR 2021 | spa |
dc.identifier.doi | 10.3390/IJMS22168448 | |
dc.rights.accessRights | openAccess | spa |
dc.subject.unesco | Enfermedad cardiovascular | spa |
dc.subject.unesco | Virus | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |